Vosodilator effect of pelargonium odoratissimum on isolated rat aorta

The vasodilator effect of Pelargonium odoratissimum was investigated using isolated rat aortic rings. Eethanolic extract has shown a profound relaxing effect on noradrenaline-precontracted aortic rings. There was a difference in the effect in the absence or presence of endothelium. Relaxing effect of the ethanolic extract was obviously more potent in the presence of endothelium. These data clearly indicate that relaxing effect of Pelargonium odoratissimum is partially endothelium-dependent

[Relaxing effect of achillea: detect the effect and the mechanism on isolated aortic rings]

The vasodilator effect of Achilea was investigated using isolated rabbit aortic rings. Both ethanolic and aqueous extracts have shown a profound relaxing effect on phenyl ephrine-precontracted aortic rings. There was no difference in the effect in the absence or presence of endothelium. Anyway, the ethanolic extract was obviously more potent than aqueous and therefore it was then chosen to continue the study to investigate the role of potassium channels. The K+ channels blockers, Glibenclamide and TEA, partially inhibited the relaxing effect of Achillea. On the other side, the ethanolic extract has also shown a relaxing effect on aortic rings precontracted by high concentration of K[+] ions [35mM]. These data clearly indicate that relaxing effect of Achillea is not endothelium-dependent but it is related to K+ channels